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Updated: Apr 30, 2026

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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
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Long-term cardiac computed tomography follow-up after left atrial appendage occlusion
Lasse Hubertus Tiroke1,2, Anders Kramer1,2, Mette Wørmer Poulsen1,2
1Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Summary
Long-term follow-up shows the Amplatzer Amulet device maintains stable left atrial appendage occlusion after >4 years. Device durability is excellent, though some peridevice leakage progression occurred, potentially linked to left atrial volume changes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Left atrial appendage occlusion (LAAO) is an increasingly utilized procedure.
- Long-term imaging data following LAAO are limited.
- The Amplatzer Amulet device is commonly used for LAAO.
Purpose of the Study:
- To evaluate the safety and durability of the Amplatzer Amulet device.
- To assess device performance more than 4 years after LAAO.
- To analyze long-term left atrial appendage sealing and peridevice leakage.
Main Methods:
- Prospective observational cohort study of 52 patients.
- Cardiac computed tomography (CT) scans at 2 months, 12 months, and >4 years post-LAAO.
- Primary outcome: LAA sealing and peridevice leakage (PDL) grading.
- Secondary outcomes: hypoattenuated thickening, device-related thrombosis, and device durability.
Main Results:
- Stable complete occlusion rates (33-37%) and moderate leaks (G2, 48-52%) observed over time.
- Minor leaks (G1) decreased, while significant leaks (G3) increased from 2% to 12%.
- No device-related thrombosis (DRT) was detected, and device integrity remained intact.
- Left atrial volume showed a trend of increase over the follow-up period.
Conclusions:
- The Amplatzer Amulet device demonstrates stable LAA sealing and excellent long-term durability.
- Procedural success is crucial for preventing peridevice leakage.
- Progression of PDL in a few patients may be associated with left atrial remodeling.
- Further research with larger cohorts is recommended.
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