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Pediatric central nervous system (CNS) neuroblastoma: A case report
Brandon Sharkey1, Kaitlin Michelle Conner1, Cade R McGarvey1
1Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States.
Surgical Neurology International
|June 6, 2024
Summary
This study presents a rare, low-grade pediatric neuroblastoma with FoxR2 gene activation. Further research is needed to understand these unusual FoxR2 tumors.
Area of Science:
- Oncology
- Pediatric Medicine
- Genetics
Background:
- Neuroblastomas are rare pediatric tumors often associated with the FoxR2 gene.
- Current diagnostic profiles are limited due to the novelty of these tumors.
- Known biomarkers include Olig2, MAP2, SOX10, ANKRD55, and synaptophysin; magnetic resonance imaging (MRI) aids identification.
Observation:
- A case report details a 2-year-old patient diagnosed with a neuroblastoma via MRI and confirmed FoxR2 gene activation.
- The tumor was surgically removed.
- Notably, this specific tumor presented as low-grade, contrasting with the typically high-grade nature of most FoxR2-activated neuroblastomas.
Findings:
- Successful surgical removal of a low-grade FoxR2-activated neuroblastoma.
- Confirmation of FoxR2 gene activation in a pediatric neuroblastoma case.
- Identification of an unusual low-grade presentation for this tumor type.
Implications:
- Highlights the need for further investigation into the diverse characteristics of FoxR2-activated neuroblastomas.
- Suggests potential for varied clinical presentations beyond high-grade malignancy.
- Emphasizes the importance of comprehensive diagnostic approaches for rare pediatric tumors.
