Calcinosis Cutis in Juvenile Systemic Sclerosis.

Area of Science:

• Pediatric Rheumatology
• Dermatology
• Autoimmune Diseases

Background:

• Juvenile systemic sclerosis (JSSc) is a rare autoimmune disorder affecting children and adolescents, characterized by excessive collagen production.
• JSSc results from a complex interplay of immunological, environmental, and genetic factors.
• Common symptoms include respiratory, cardiovascular, and gastrointestinal issues, but calcinosis cutis is exceptionally rare in JSSc.

Observation:

• A 14-year-old female presented with acute breathlessness and chronic sacral lesions.
• The patient exhibited multiple lesions in the sacral region, indicative of calcinosis cutis.
• Surgical excision was performed for the calcinosis cutis in dependent areas.

Findings:

• This case report documents an extremely rare instance of calcinosis cutis in a pediatric patient with juvenile systemic sclerosis.
• The presentation of acute breathlessness alongside chronic skin lesions suggests potential complications or co-existing conditions.

Implications:

• The occurrence of calcinosis cutis in JSSc, though rare, necessitates its consideration in the differential diagnosis.
• Prompt diagnosis and intervention are crucial for managing JSSc and preventing severe outcomes, including mortality.
• This case underscores the importance of comprehensive evaluation in pediatric autoimmune diseases.