Prognostic significance of TNFRSF4 expression and development of a pathomics model to predict expression in hepatocellular carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) expression and a new pathomics model show promise as prognostic markers for hepatocellular carcinoma (HCC) survival. Gender impacts how these markers relate to patient outcomes.
Area Of Science
- Oncology
- Molecular Biology
- Pathology
Background
- Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is implicated in cancer progression, particularly in hepatocellular carcinoma (HCC).
- Understanding TNFRSF4's prognostic value in HCC is crucial for improving patient outcomes.
Purpose Of The Study
- To investigate the prognostic significance of TNFRSF4 expression in HCC patients.
- To develop and validate a predictive pathomics model for TNFRSF4 expression in HCC.
Main Methods
- RNA-sequencing analysis of HCC patient cohort from TCGA database to assess TNFRSF4 expression and overall survival (OS).
- Hematoxylin-eosin staining and analysis to construct a pathomics model for predicting TNFRSF4 expression.
- Pathway enrichment, immune checkpoint marker, and immune cell infiltration analyses to elucidate biological mechanisms.
Main Results
- TNFRSF4 expression was elevated in HCC tumor tissues and correlated with advanced pathologic stage and residual tumor status.
- Higher TNFRSF4 expression was linked to unfavorable OS, especially in male HCC patients.
- The pathomics model accurately predicted TNFRSF4 expression and associated high scores with worse OS and increased mortality risk in males, implicating pathways like EMT and Tregs.
Conclusions
- TNFRSF4 expression and pathomics scores serve as potential prognostic biomarkers for HCC OS.
- Gender is a significant factor influencing the prognostic association of TNFRSF4 and pathomics scores in HCC.
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