Genome-wide DNA methylation profiles and breast cancer among World Trade Center survivors
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View abstract on PubMed
Summary
This summary is machine-generated.World Trade Center (WTC) exposure is linked to altered DNA methylation patterns in cancer-free and breast cancer patients. These epigenetic changes may increase cancer risk through immune system pathways.
Area Of Science
- Environmental Epidemiology
- Epigenetics
- Cancer Biology
Background
- World Trade Center (WTC) exposure is associated with increased cancer incidence.
- Aberrant DNA methylation is a key factor in cancer development.
- Limited research exists on WTC exposure and DNA methylation.
Purpose Of The Study
- To investigate DNA methylation profiles in WTC-exposed individuals.
- To compare methylation patterns between WTC-exposed cancer-free individuals and those with breast cancer.
- To identify potential epigenetic links between WTC exposure and cancer development.
Main Methods
- Selected WTC-exposed women from the WTC Environmental Health Center clinic.
- Used a WTC-unexposed cohort (NYU Women's Health Study) as a reference.
- Employed the Infinium MethylationEPIC array for global DNA methylation profiling.
- Adjusted for cell type composition and other confounders.
- Conducted biological pathway and network analysis on annotated probes.
Main Results
- WTC-exposed individuals showed a higher prevalence of hypermethylated cytosine-phosphate-guanine sites.
- Cancer-related pathways, including human papillomavirus infection and cGMP-PKG signaling, were overrepresented in WTC-exposed groups.
- Identified 47 epigenetically dysregulated genes in WTC-exposed breast cancers compared to unexposed patients.
- Discovered a gene network involving Wnt/β-catenin signaling (WNT4, TCF7L2) linked to cancer immune evasion.
Conclusions
- WTC exposure appears to influence DNA methylation patterns.
- These epigenetic alterations may contribute to cancer predisposition.
- An immune-mediated mechanism might be involved in WTC-related cancer development.
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