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Updated: Jun 24, 2025
10:42
A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
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Olfactory dysfunction as an early predictor for post-COVID condition at 1-year follow-up
Christoffer Granvik1, Sara Andersson2, Linus Andersson3
1Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
Brain and Behavior
|June 6, 2024
Summary
Objective olfactory dysfunction 1-3 months after COVID-19 predicts long-term post-COVID condition (PCC+). Early olfactory screening may identify individuals at higher risk for developing persistent symptoms and reduced quality of life.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Post-COVID condition (PCC) often involves olfactory, neurological, and cognitive deficits.
- Understanding predictors of PCC is crucial for early intervention and management.
Purpose of the Study:
- To investigate if olfactory and neuropsychological test performance post-COVID-19 infection predicts long-term PCC.
- To identify individuals at risk for persistent symptoms and reduced quality of life.
Main Methods:
- Prospective cohort study of hospitalized and non-hospitalized individuals (N=66).
- Olfactory threshold and neuropsychological tests administered 1-3 months post-infection.
- Persistent symptoms and health-related quality of life assessed 1 year post-infection.
Main Results:
- Objectively assessed olfactory dysfunction, not subjective symptoms, predicted PCC+ at 1 year.
- PCC+ group showed higher rates of mild cognitive impairment and fatigue.
Conclusions:
- Objective olfactory dysfunction is a significant predictor of long-term post-COVID condition.
- Early olfactory screening can identify individuals at higher risk for developing long-term sequelae.
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