[Modern Fixed Combinations in the Correction of Arterial Hypertension and Dyslipidemia]

Z M Galeeva1, A S Galyavich1, L V Baleeva1

  • 1Kazan State Medical University.

Kardiologiia
|June 6, 2024
PubMed

Insights

This case report highlights the personalized treatment of arterial hypertension and dyslipidemia using a fixed-combination therapy. Equamer® (amlodipine, lisinopril, rosuvastatin) effectively addressed key cardiovascular disease risk factors.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Arterial hypertension and dyslipidemia are significant risk factors for cardiovascular diseases.
  • Ischemic heart disease often coexists with arterial hypertension, necessitating targeted therapeutic strategies.

Purpose of the Study:

  • To present a clinical case demonstrating the individual selection of effective therapy for a patient with arterial hypertension and dyslipidemia.
  • To evaluate the appropriateness of a fixed triple combination therapy in managing combined cardiovascular risk factors.

Main Methods:

  • A clinical case report approach was utilized.
  • Therapeutic selection was based on patient-specific risk factors and clinical guidelines.
  • Equamer® (amlodipine + lisinopril + rosuvastatin) was chosen as the fixed-combination therapy.

Main Results:

  • The selected fixed triple combination therapy (amlodipine, lisinopril, rosuvastatin) was deemed highly appropriate for the patient's clinical profile.
  • This combination effectively targets both arterial hypertension and dyslipidemia, major contributors to cardiovascular risk.

Conclusions:

  • Individualized therapy selection is crucial for managing complex cardiovascular conditions.
  • Fixed triple combination therapy, such as Equamer®, offers a rational approach to addressing multiple cardiovascular risk factors simultaneously.

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
421
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
647
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
157
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
1.9K
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
363
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
503