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Association of Interleukin-6 (rs1800795) and Interleukin-10 (rs1800896) Genetic Polymorphisms with the Outcome of

Mahmoud El-Bendary1,2, Mustafa Naemattalah2,3, Hatem Elalfy1,2

  • 1Tropical Medicine and Hepatogastroenterology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Viral Immunology
|June 6, 2024
PubMed

Insights

Genetic variations in interleukin-6 (IL-6) and interleukin-10 (IL-10) genes are linked to COVID-19 severity. The C allele of IL-6 (rs1800795) and IL-10 (rs1800896) were significantly associated with severe COVID-19 outcomes.

Area of Science:

  • Immunogenetics
  • Infectious Disease Epidemiology
  • Molecular Biology

Background:

  • The COVID-19 pandemic highlights the need to understand factors influencing disease severity.
  • Genetic polymorphisms, particularly in cytokine genes, may play a role in differential host responses to SARS-CoV-2 infection.

Purpose of the Study:

  • To investigate the association between specific genetic polymorphisms in interleukin-6 (IL-6) and interleukin-10 (IL-10) genes and the clinical outcomes of COVID-19.
  • To determine if these genetic variations correlate with disease severity (moderate vs. severe) and mortality.

Main Methods:

  • A cross-sectional study involving 354 COVID-19 patients categorized into moderate and severe groups.
  • Genotyping was performed for single nucleotide polymorphisms (SNPs) IL-6 rs1800795 and IL-10 rs1800896 using real-time PCR.
  • Statistical analysis was employed to compare allele frequencies between patient groups.

Main Results:

  • The C allele of IL-6 rs1800795 was significantly more prevalent in severe COVID-19 cases compared to moderate cases (p < 0.0001).
  • The C allele of IL-10 rs1800896 also showed a significant increase in severe cases versus moderate cases (p < 0.0001).
  • IL-6 C allele carriage showed a mild significant association with mortality (alive vs. deceased, p < 0.04), while IL-10 did not show a significant difference in mortality.

Conclusions:

  • The C alleles of IL-6 rs1800795 and IL-10 rs1800896 are significantly associated with increased severity of COVID-19.
  • IL-6 genetic variations may influence survival outcomes in COVID-19 patients, warranting further investigation.

Keywords:
COVID-19IL-10IL-6SARSgenetic polymorphism

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