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Taming Molecular Folding: Anion-Templated Foldamers with Tunable Quaternary Structures
Eric A John1, Asia Marie S Riel1, Lianne H E Wieske2
1Department of Chemistry and Biochemistry, University of Montana, Missoula, Montana 59812, United States.
Journal of the American Chemical Society
|June 6, 2024
Summary
Researchers engineered higher-order foldamers using halogen and hydrogen bonding to create novel anion-templated double helices. This breakthrough offers new design strategies for specific guest binding in supramolecular chemistry.
Area of Science:
- Supramolecular Chemistry
- Molecular Design
- Organic Chemistry
Background:
- Foldamers are unique supramolecules with diverse applications.
- Controlling higher-order structures in foldamers is crucial for advanced molecular design.
Purpose of the Study:
- To develop a novel method for controlling quaternary folding in foldamers.
- To investigate the combined effects of halogen bonding (XBing) and hydrogen bonding (HBing) on foldamer structure.
- To present the first anion-templated double helices induced by halogen bonds.
Main Methods:
- Utilized a combination of halogen bonding and hydrogen bonding interactions.
- Designed and synthesized two similar oligomers with varying HB and XB donor arrangements.
- Characterized the quaternary structure and guest binding properties of the foldamers.
Main Results:
- Successfully induced and stabilized anion-templated double helices using halogen bonds (XBs) and hydrogen bond enhanced halogen bonds (HBeXBs).
- Demonstrated that the number and orientation of HB and XB donors significantly influence quaternary structure.
- Showcased the impact of structural modifications on guest selectivity.
Conclusions:
- This research introduces a novel approach to engineer foldamer quaternary structures.
- The findings provide new design principles for creating foldamers with tailored guest-binding capabilities.
- Highlights the synergistic role of halogen and hydrogen bonding in supramolecular assembly.
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