Factors predictive of recurrence, metastasis and death in node-negative penile squamous cell carcinoma: A retrospective multicentre cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.History of balanitis and phimosis, along with poor differentiation, corporal invasion, and perineural invasion (PNI), are key prognostic factors for penile squamous cell carcinoma (PSCC) outcomes.
Area Of Science
- Oncology
- Urology
- Pathology
Background
- Penile squamous cell carcinoma (PSCC) is associated with significant morbidity and mortality.
- Limited data exists on prognostic factors, particularly for metastasis development in PSCC.
Purpose Of The Study
- To identify independent prognostic factors for adverse outcomes in clinically node-negative PSCC patients.
- Outcomes evaluated include local recurrence (LR), metastasis, and disease-specific death (DSD).
Main Methods
- A 32-year retrospective multicenter cohort study.
- Included 265 patients with histologically diagnosed PSCC.
- Developed predictive models based on patient and tumor characteristics.
Main Results
- Five independent prognostic factors for poor outcomes were identified: history of balanitis, poor differentiation, corporal invasion, perineural invasion (PNI), and history of phimosis.
- Poor differentiation, PNI, and corporal invasion were significantly associated with increased metastasis risk.
- Higher 5-year cumulative incidence of metastasis was observed for tumors with PNI, corporal invasion, and poor differentiation.
Conclusions
- History of balanitis, phimosis, PNI, corporal invasion, and poor differentiation are independent risk factors for adverse outcomes in PSCC.
- Prognostic staging for PSCC may be improved, as poor differentiation and PNI are currently classified under T1b disease.
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