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Updated: Jun 24, 2025
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Outcomes of interventions in neonatal sepsis: A systematic review of qualitative research
Petek Eylul Taneri1,2, Declan Devane1,2,3, Jamie Kirkham4
1HRB-Trials Methodology Research Network, University of Galway, Galway, Ireland.
Background:
While a systematic review exists detailing neonatal sepsis outcomes from clinical trials, there remains an absence of a qualitative systematic review capturing the perspectives of key stakeholders.
Objectives:
Our aim is to identify outcomes from qualitative research on any intervention to prevent or improve the outcomes of neonatal sepsis that are important to parents, other family members, healthcare providers, policymakers, and researchers as a part of the development of a core outcome set (COS) for neonatal sepsis.
Search Strategy:
A literature search was carried out using MEDLINE, EMBASE, CINAHL, and PsycInfo databases.
Selection Criteria:
Publications describing qualitative data relating to neonatal sepsis outcomes were included.
Data Collection And Analysis:
Drawing on the concepts of thematic synthesis, texts related to outcomes were coded and grouped. These outcomes were then mapped to the domain headings of an existing model.
Main Results:
Out of 6777 records screened, six studies were included. Overall, 19 outcomes were extracted from the included studies. The most frequently reported outcomes were those in the domains related to parents, healthcare workers and individual organ systemas such as gastrointestinal system. The remaining outcomes were classified under the headings of general outcomes, miscellaneous outcomes, survival, and infection.
Conclusions:
The outcomes identified in this review are different from those reported in neonatal sepsis clinical trials, thus highlighting the importance of incorporating qualitative studies into COS development to encapsulate all relevant stakeholders' perspectives.
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