Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds
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View abstract on PubMed
Summary
This summary is machine-generated.Analyzing ancient dog fur reveals the origins of Nordic dog breeds like the Lapphund and Elkhound. Genetic analysis identified key genes, including MSRB3, influencing ear morphology due to artificial selection.
Area Of Science
- Canine genetics
- Evolutionary biology
- Population genomics
Background
- The origins and morphological evolution of modern dog breeds are challenging to study due to extinct founder populations.
- Understanding breed development requires analyzing genetic diversity and selection pressures.
Purpose Of The Study
- To investigate the origin and artificial selection of Nordic Lapphund and Elkhound dog breeds.
- To explore the utility of ancient dog artifacts in genetic studies.
Main Methods
- Population genomic analysis of eight ancient dog fur samples (100-200 years old).
- Identification of genes under positive selection.
- Functional assays to investigate gene expression regulation (SNP mutation, miRNA).
Main Results
- Confirmed Lapphund and Elkhound breeds originate from local populations with reduced genetic diversity.
- Identified eleven genes under positive selection during breed development.
- MSRB3 gene, linked to ear morphology, showed selection; a SNP mutation suppresses its expression via miRNA regulation.
Conclusions
- Ancient dog artifacts are effective for studying the origin and artificial selection of modern dog breeds.
- Genetic analysis reveals specific selection events shaping Nordic dog breeds.
- MSRB3 gene regulation provides insights into breed-specific morphological traits.
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