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Updated: Jun 24, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Disulfide Bonds as Functional Tethers in Metal-Organic Frameworks
Jennifer M Moore1, Douglas T Genna1
1Department of Chemical and Biological Sciences, Youngstown State University, 44555, Youngstown, Ohio, USA.
Abstract:
The functionality of metal-organic frameworks (MOFs) is often encoded by specific chemical moieties found within these architectures. As such, new techniques to install increasingly more complex functionalities in MOFs are regularly being reported in the literature. One such functional group is the disulfide bond. The redox behavior of this covalent linkage renders MOFs responsive to stimuli, often under reducing conditions. Here, we review examples in which disulfide-containing MOFs are deployed in applications including drug delivery, therapeutic ferroptosis, exfoliation, energy storage, sensing, and others.
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