The Relationship between the Level of Coagulative Function Hypertensive Disorder Complicating Pregnancy

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Pathophysiology

Background:

• Preeclampsia is a serious pregnancy complication with high maternal and perinatal mortality.
• The blood coagulation-fibrinolysis system is implicated in preeclampsia, but its specific hematologic markers remain unclear.
• Understanding these markers is crucial for predicting preeclampsia severity and onset.

Purpose of the Study:

• To identify distinct hematologic parameters in preeclamptic and normotensive pregnant women.
• To assess the significance of these parameters in the pathogenesis and severity of preeclampsia.

Main Methods:

• A cohort of 112 patients with gestational hypertension was divided into early-onset (32) and late-onset (80) preeclampsia groups.
• A control group of 82 normotensive pregnant women was included for comparison.
• Key hematologic parameters were analyzed in all participants.

Main Results:

• Mild and severe preeclampsia showed lower hemoglobin levels.
• Higher mean platelet volume and fibrinogen levels were observed in preeclampsia.
• Shorter prothrombin time and activated partial thromboplastin time were associated with preeclampsia.

Conclusions:

• Hematologic parameters are significantly altered in preeclampsia.
• These findings highlight the role of coagulation factors in preeclampsia pathogenesis and severity.
• Specific blood test results may aid in assessing preeclampsia.