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Antimicrobial susceptibility of Pasteurella multocida strains isolated from different host species

Krisztina Pintér1, Boglárka Dóra Pollák1, Hubert Gantelet2

  • 11HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.

Acta Veterinaria Hungarica
|June 6, 2024
PubMed

Insights

Antibiotic resistance is a major challenge. Testing Pasteurella multocida strains revealed effective antibiotics like ceftiofur, but also identified multi-drug resistant (MDR) strains, highlighting the need for susceptibility profiling.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance Research

Background:

  • Antibiotic resistance poses a significant global health threat, complicating bacterial disease treatment.
  • Pasteurella multocida is a common facultative pathogen causing diverse diseases in animals.

Purpose of the Study:

  • To evaluate the antibiotic susceptibility profile of Pasteurella multocida strains.
  • To identify effective antimicrobial agents for treating pasteurellosis.
  • To assess the prevalence of multi-drug resistant (MDR) strains.

Main Methods:

  • Antibiotic susceptibility testing of 155 P. multocida isolates.
  • Broth microdilution method to determine Minimum Inhibitory Concentration (MIC) values.
  • Evaluation against 15 different antibiotics.

Main Results:

  • Ceftiofur, tetracycline, doxycycline, florfenicol, and tilmicosin demonstrated high efficacy.
  • Twelve strains exhibited multi-drug resistance (MDR).
  • Significant variation in susceptibility patterns was observed across strains.

Conclusions:

  • Establishing pre-treatment antibiotic susceptibility profiles is crucial for effective pasteurellosis treatment.
  • Judicious antibiotic selection can improve treatment success and mitigate resistance spread.
  • Monitoring and combating MDR strains of P. multocida is essential.
Keywords:
MICPasteurella multocidaantimicrobial resistance

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