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The pharmacokinetics of cimetidine and metabolites in a neonate
Limited pharmacokinetic data have been reported concerning the use of cimetidine in the neonate for the management of gastrointestinal hemorrhage. After receiving cimetidine at a dose of 10 mg/kg/d in a full-term infant, the steady-state peak and four-hour concentrations were 3.5 and 1.8 micrograms/ml, respectively. A mean half-life of 3.6 h for cimetidine and 2.2 h for cimetidine sulfoxide were determined. The cimetidine half-life was prolonged, and the total body clearance decreased as compared with values reported in critically ill children and adults.
Limited pharmacokinetic data have been reported concerning the use of cimetidine in the neonate for the management of gastrointestinal hemorrhage. After receiving cimetidine at a dose of 10 mg/kg/d in a full-term infant, the steady-state peak and four-hour concentrations were 3.5 and 1.8 micrograms/ml, respectively. A mean half-life of 3.6 h for cimetidine and 2.2 h for cimetidine sulfoxide were determined. The cimetidine half-life was prolonged, and the total body clearance decreased as compared with values reported in critically ill children and adults.