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Cellular metabolism and hypoxia interfacing with allergic diseases
Shauna K Kellett1, Joanne C Masterson1,2,3
1Allergy, Inflammation & Remodelling Research Laboratory, Department of Biology, Maynooth University, Maynooth, W23 C2N1, County Kildare, Ireland.
Journal of Leukocyte Biology
|June 6, 2024
Summary
Metabolic dysfunction and hypoxia responses are increasingly recognized as key factors in allergic diseases. Understanding these links may lead to new targeted treatments for rising allergy prevalence.
Area of Science:
- Immunology
- Metabolic pathways
- Allergic disease pathogenesis
Background:
- Allergic diseases exhibit complex and heterogeneous pathogenesis.
- Rising prevalence highlights the need to understand underlying mechanisms.
- Upregulated hypoxia response is associated with inflammation and tissue remodeling in allergies.
Purpose of the Study:
- To review current understanding of metabolic dysfunction in allergic diseases.
- To explore the role of cellular metabolism in immune and stromal cell activation during allergic sensitization.
- To identify potential therapeutic targets within immune metabolic pathways.
Main Methods:
- Review of current scientific literature.
- Analysis of data from "omic" techniques (e.g., lipidomics, metabolomics).
- Examination of biomarkers in various allergic disease models.
Main Results:
- "Omic" technologies reveal biomarkers like altered lipid species, nutrient transporters, and amino acids in allergic diseases.
- Hypoxia response is linked to inflammatory cell infiltration and increased metabolic demands.
- Dynamic metabolic changes are crucial for immune cell activation in allergic sensitization.
Conclusions:
- Metabolic dysfunction is a significant factor in allergic disease pathogenesis.
- Identifying and integrating metabolic alterations can enhance understanding of disease mechanisms.
- Targeting immune metabolic pathways offers a novel therapeutic strategy for allergic diseases.
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