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Abietane diterpenoids from Isodon amethystoides and their biological activities
Lang Zhou1, Chen-Liang Zhao2, Chuan-Yan Xu3
1College of Pharmacy, Guizhou University of Traditional Chinese Medicine, No. 4 Dongqing South Road, Guiyang, Guizhou, 550002, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University / Natural Products Research Center of Guizhou Province, Guizhou, 550014, PR China.
Abstract:
Seven undescribed abietane diterpenoids [abietamethinols A-G (1-7)] were isolated from the twigs and leaves of Isodon amethystoides. Their structures were elucidated on the basis of spectroscopic methods including 2D NMR, and they were further confirmed by X-ray crystallographic data. Lophanic acid was considered as the precursor of 1-7 in the biosynthesis pathway hypothesis. These compounds were evaluated for their cytotoxic, anti-bacterial and anti-AIV (avian influenza virus) activities. Compound 5 showed 42.9% inhibitory activity against the cancer cell line SMMC-7721 at the concentration of 40 μM, 3 and 4 could inhibit the bacterial growth of Streptococcus sobrinus by 55.3% and 63.2% at the concentrations of 148.6 and 141.9 μM, respectively, and 4 was demonstrated with antiviral activity against AIV with the inhibitory effect of 68.4% at 25 μM.
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