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Updated: Jun 24, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

A Practical Primer on Particle Therapy.

Timothy D Malouff¹, Mark Newpower², Aaron Bush³

¹Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Practical Radiation Oncology

|June 6, 2024

Summary

This summary is machine-generated.

Particle therapy, including proton beam therapy, offers unique physical and radiobiological properties. Protons, helium, and carbon ions are most common, with multi-ion therapy emerging.

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Area of Science:

Medical Physics
Radiation Oncology
Particle Therapy

Background:

Particle therapy is an evolving cancer treatment modality.
Proton beam therapy is the most prevalent form, but other ions are utilized.
Each particle possesses distinct physical and radiobiological characteristics.

Purpose of the Study:

To review and compare the properties of various particles used in therapy.
To discuss radiobiological and physical aspects of different ions.
To summarize existing clinical data for practicing clinicians.

Main Methods:

PubMed database search for relevant studies.
Inclusion of articles on radiobiology, physics, and clinical applications.
Narrative review synthesizing findings from 113 sources.

Main Results:

Proton beam therapy is the most studied and widely used particle therapy.
Carbon, helium, and neutrons follow in clinical use.
Oxygen, neon, silicon, and argon have limited clinical use as monotherapy.

Conclusions:

This review consolidates information on clinically relevant particles.
Protons, helium, and carbon are expected to remain the primary choices.
Multi-ion particle therapy represents a developing treatment strategy.