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Identification of a macrocyclic compound targeting the lassa virus polymerase

Virginia Aida-Ficken1, Jamie A Kelly2, Payel Chatterjee2

  • 1Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA; Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.

Antiviral Research
|June 6, 2024
PubMed
Summary

Researchers screened nearly 60,000 compounds to find treatments for Lassa virus (LASV). The potent compound Mac128 showed significant activity against LASV, inhibiting viral replication.

Keywords:
AntiviralLassaMacrocyclePolymerase

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