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Published on: January 28, 2020
Cardiometabolic Co-morbidity Burden and Circulating Biomarkers in Patients With Chronic Coronary Disease in the
Carine E Hamo1, Richard Liu2, Wenbo Wu2
1Department of Medicine, NYU Grossman School of Medicine, New York, New York.
Higher cardiometabolic comorbidity burden, including diabetes, hypertension, and obesity, in patients with coronary artery disease correlates with increased biomarkers of myocardial injury and inflammation. This highlights the impact of uncontrolled conditions on cardiovascular health.
Area of Science:
- Cardiology
- Biomarkers
- Chronic Disease Management
Background:
- Cardiometabolic conditions like diabetes, hypertension, and obesity are major contributors to cardiovascular disease.
- Circulating biomarkers are crucial for prognostication in cardiovascular disease patients.
- Understanding the link between comorbidity burden and specific biomarkers can refine risk assessment.
Purpose of the Study:
- To investigate the association between the burden of cardiometabolic comorbidities and specific plasma biomarkers in patients with chronic coronary disease.
- To examine biomarkers related to myocardial stretch, injury, inflammation, and platelet activity in relation to comorbidity severity.
Main Methods:
- Analysis of plasma biomarkers (NT-proBNP, hs-cTnT, hs-CRP, IL-6, sCD40L, GDF-15) and clinical risk factors (HbA1c, SBP, BMI) from ISCHEMIA trial participants.
- Definition and categorization of cardiometabolic comorbidities (DM, HTN, obesity) based on severity and control levels.
- Linear regression models adjusted for relevant covariates to assess associations between comorbidity burden and biomarker levels.
Main Results:
- Participants with a greater cardiometabolic comorbidity burden included those with Black race, current smokers, and history of myocardial infarction or heart failure.
- The presence of at least one severely uncontrolled comorbidity was linked to significantly elevated levels of hs-cTnT, hs-CRP, IL-6, and GDF-15.
- Increased cardiometabolic comorbidity burden showed a significant association with higher levels of myocardial injury and inflammation biomarkers.
Conclusions:
- Increasing cardiometabolic comorbidity burden in patients with chronic coronary disease is associated with elevated circulating biomarkers of myocardial injury and inflammation.
- These findings underscore the importance of managing comorbidities to mitigate cardiovascular risk.
- Biomarker profiling in conjunction with comorbidity assessment may offer deeper insights into patient prognosis.
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