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  11. Epidemiology Of Early Vs Late Recurrence Among Women With Early Stage Estrogen Receptor-positive Breast Cancer In The Pathways Study

Epidemiology of early vs late recurrence among women with early stage estrogen receptor-positive breast cancer in the Pathways Study

Alfredo V Chua1, Haiyang Sheng1, Emily Liang2

  • 1Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Journal of the National Cancer Institute
|June 6, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Progesterone receptor negativity and race/ethnicity impact early recurrence risk in estrogen receptor-positive breast cancer. Minoritized groups face higher early recurrence, highlighting potential disparities.

Area of Science:

  • Oncology
  • Breast Cancer Research
  • Cancer Epidemiology

Background:

  • Limited understanding of prognostic factors differentiating early versus late recurrence in early-stage estrogen receptor-positive breast cancer.
  • Estrogen receptor-positive breast cancer represents a significant proportion of breast cancer diagnoses, making recurrence patterns crucial for patient outcomes.

Purpose of the Study:

  • To investigate and compare the prognostic factors associated with early (<5 years) versus late (≥5 years) recurrence in early-stage estrogen receptor-positive breast cancer.
  • To identify distinct clinical and demographic predictors for different recurrence timings in this patient population.

Main Methods:

  • Analysis of a prospective cohort (Pathways Study) of 2992 women with stage I-IIB estrogen receptor-positive breast cancer.
  • Prospective enrollment between 2006-2013 with recurrence and death data ascertained through December 2021.

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  • Statistical analysis to compare factors associated with early vs. late recurrence, including multivariable models.

    • Main Results:

    • Higher tumor stage and grade were linked to recurrence irrespective of timing.
    • Progesterone receptor negativity was associated with early recurrence but not late recurrence.
    • Marmorized racial and ethnic groups (Asian, Black, Hispanic) showed a higher risk of early recurrence compared to non-Hispanic White women, a trend persisting after adjustments.

    Conclusions:

    • Progesterone receptor status and self-identified race/ethnicity are important factors distinguishing early from late recurrence in estrogen receptor-positive breast cancer.
    • Elevated early recurrence risk in Asian, Black, and Hispanic women suggests potential disparities in cancer outcomes within this generally favorable breast cancer subtype.