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Unveiling brain disorders using liquid biopsy and Raman spectroscopy
Jeewan C Ranasinghe1, Ziyang Wang1, Shengxi Huang1
1Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA. shengxi.huang@rice.edu.
Nanoscale
|June 7, 2024
Summary
Raman spectroscopy (RS) offers a new, non-invasive method for diagnosing brain disorders like neurodegenerative diseases (NDs) and traumatic brain injury (TBI) by analyzing liquid biopsies for molecular signatures.
Area of Science:
- Neuroscience
- Biochemistry
- Spectroscopy
Background:
- Early diagnosis of brain disorders (neurodegenerative diseases, traumatic brain injury) is challenging.
- Conventional imaging lacks molecular specificity; liquid biopsy offers minimally invasive insights.
- Raman spectroscopy (RS) provides rich molecular data cost-effectively.
Purpose of the Study:
- To explore the role of Raman spectroscopy (RS) in diagnosing brain disorders.
- To highlight RS's potential in analyzing liquid biopsies for early detection and monitoring.
- To review current advancements and future prospects of RS in neurodisorder diagnostics.
Main Methods:
- Analysis of liquid biopsy samples (blood, CSF, saliva, tears).
- Application of Raman spectroscopy for molecular signature detection.
- Utilizing enhanced Raman technologies and advanced data analysis.
Main Results:
- RS can detect intricate molecular signatures in biological fluids.
- Developments enhance RS applicability for probing disease pathology.
- RS shows potential for molecularly specific disease characterization.
Conclusions:
- Raman spectroscopy is an emerging, non-invasive tool for brain disorder diagnosis.
- Liquid biopsy analysis via RS offers significant potential for early detection and continuous monitoring.
- RS advancements promise transformative impact on understanding and managing NDs and TBI.
