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Published on: February 8, 2019
Non-invasive measurement of rat auditory evoked fields using an optically pumped atomic magnetometer: Effects of task
Yi Ruan1, Zhao Xiang1, Guanzhong Lu1
1Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, 310023, China.
Abstract:
Optically pumped magnetometers (OPMs) have become a favorable tool for magnetoencephalography (MEG) measurement, offering a non-invasive method of measurement. OPMs do not require cryogenic environments, sensors can be more closely aligned with the brain. We employed a passive single-stimulus paradigm in conjunction with OPMs with a sensitivity of 20 fT/ to investigate the auditory response of rats to inter-stimulus interval (ISI) and frequencies, recording the rat auditory event-related magnetic fields (ERMFs). Our findings include: (1) Auditory evoked fields can be detected non-invasively by OPMs; (2) The amplitude of the rat auditory ERMFs varies with changes in ISI, with more pronounced amplitude changes observed after 5 s; (3) When the sound stimulus frequency is altered at the same ISI, the amplitude of the rats ERMFs changes with frequency, indicating significant differences in attention. Our method offers a valuable tool for the clinical application of a single stimulus paradigm and opens up a new avenue for research on the brain magnetic field detections.
