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Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
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The relationship between potassium levels and 28-day mortality in sepsis patients: Secondary data analysis using the

Juan Tang1,2, Peiling Zhao1, Yi Li1,2

  • 1Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, 28, Guiyi Street, Guiyang, Guizhou, China.

Heliyon
|June 7, 2024
PubMed
Abstract

Insights

Serum potassium levels impact sepsis patient survival. Both high and low levels are linked to increased 28-day mortality risk in sepsis patients, highlighting a critical U-shaped relationship.

Area of Science:

  • Critical Care Medicine
  • Clinical Chemistry
  • Epidemiology

Background:

  • The relationship between serum potassium levels and mortality in sepsis patients requires further investigation.
  • Existing research on this topic presents conflicting findings.

Purpose of the Study:

  • To examine the association between serum potassium levels and 28-day mortality in sepsis patients.
  • To add to the evidence base concerning potassium's role in sepsis outcomes.

Main Methods:

  • Retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.
  • Inclusion of 349,080 sepsis patients.
  • Serum potassium on ICU admission as the exposure, 28-day mortality as the outcome, controlling for confounders.

Main Results:

  • A U-shaped relationship was observed between serum potassium and 28-day mortality.
  • The inflection point was identified at 4.10 mmol/L.
  • Below 4.10 mmol/L, lower potassium was linked to lower mortality; above 4.10 mmol/L, higher potassium was linked to higher mortality.

Conclusions:

  • Both excessively high and low serum potassium levels are associated with an increased risk of 28-day mortality in sepsis patients.
  • These findings underscore the importance of monitoring and managing potassium levels in sepsis management.
Keywords:
28 day-mortalityPotassiumSepsis

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