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An alternative method for inferring Pandy's test using cerebrospinal fluid total protein
Liu Dong1, Xiaoqing Wang1, Qianqian Xu1
1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Practical Laboratory Medicine
|June 7, 2024
Summary
Pandy's test, a manual method for cerebrospinal fluid globulin, can be accurately estimated using cerebrospinal fluid total protein (CSF-TP) quantification. This correlation allows for the potential replacement of the traditional Pandy's test.
Area of Science:
- Clinical Chemistry
- Neurology
- Laboratory Medicine
Background:
- Pandy's test is a traditional semi-quantitative method for assessing globulin levels in cerebrospinal fluid (CSF).
- The clinical utility and practicality of Pandy's test have been questioned due to its manual and subjective nature.
Purpose of the Study:
- To investigate the correlation between cerebrospinal fluid total protein (CSF-TP) quantification and Pandy's test results.
- To develop a formula for estimating Pandy's test outcomes based solely on CSF-TP levels.
Main Methods:
- A retrospective analysis of 1090 patient samples with documented Pandy's test and CSF-TP results.
- Samples were categorized into six groups based on Pandy's test results for comparative analysis.
- An additional 364 patients were included for verification of the established correlation.
Main Results:
- A strong correlation was observed between CSF-TP levels and Pandy's test results.
- Specific CSF-TP ranges were defined to predict Pandy's test outcomes from negative to strongest positive.
- Verification with 364 additional samples confirmed the accuracy, with an R ratio greater than 90% for each Pandy group.
Conclusions:
- CSF-TP quantification demonstrates an excellent correlation with Pandy's test results.
- CSF-TP measurement offers a reliable method to infer Pandy's test outcomes, potentially facilitating the discontinuation of the manual Pandy's test.
