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Correlation between the triglyceride-glucose index and chronic kidney disease among adults with metabolic-associated fatty liver disease: fourteen-year follow-up

  • 0Department of Scientific Cooperation of Guangxi Academy of Medical Sciences, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Frontiers in Endocrinology +

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June 7, 2024

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June 7, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The triglyceride-glucose (TyG) index is linked to a higher risk of chronic kidney disease (CKD) in adults with metabolic dysfunction-associated fatty liver disease (MAFLD). This association is particularly strong in younger individuals, suggesting early intervention is crucial.

Area Of Science

  • Metabolic Syndrome
  • Nephrology
  • Hepatology

Background

  • The triglyceride-glucose (TyG) index is a marker of insulin resistance.
  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is prevalent and associated with metabolic comorbidities.
  • The relationship between the TyG index and chronic kidney disease (CKD) in MAFLD patients remains understudied.

Purpose Of The Study

  • To investigate the association between the TyG index and the incidence of CKD.
  • To explore this relationship specifically within a cohort of adults diagnosed with MAFLD.

Main Methods

  • Retrospective observational cohort study.
  • Included 11,860 participants with MAFLD, with data collected between 2008 and 2015.
  • CKD defined as eGFR < 60 mL/min/1.73 m² or proteinuria; follow-up median 10.02 years.

Main Results

  • A significant correlation was found between higher TyG index levels and increased CKD incidence.
  • Individuals in the highest TyG index quartile had a 1.8-fold increased risk of CKD compared to the lowest quartile.
  • The association was more pronounced in participants younger than 60 years.

Conclusions

  • Elevated TyG index is a potential risk factor for CKD development in adults with MAFLD.
  • Early monitoring and intervention targeting the TyG index may be beneficial for preventing CKD in this population.
  • Younger MAFLD patients with high TyG index require particular attention for CKD risk stratification.

Keywords:

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