Related Experiment Video
Updated: Jun 24, 2025
06:51
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
5.3K
Infantile Hemangioma Mimics Dermatofibrosarcoma Protuberans.
Joshua Wright1, Jonathan Metts2, Hector Monforte3
1Division of Plastic and Reconstructive Surgery, Johns Hopkins All Children's Hospital, St. Petersburg, Florida.
Eplasty
|June 7, 2024
Summary
Infantile hemangiomas are common, but mimics like dermatofibrosarcoma protuberans require careful diagnosis. Recognizing red flags ensures timely referral and appropriate management for these pediatric skin conditions.
Area of Science:
- Dermatology
- Pediatric Oncology
Background:
- Infantile hemangiomas (IHs) are common benign vascular tumors in infants.
- Early diagnosis and management of IHs are crucial for optimal outcomes.
- Differential diagnoses can mimic IHs, necessitating awareness of concerning presentations.
Observation:
- This report details a case of dermatofibrosarcoma protuberans (DFSP), a rare soft tissue sarcoma, mimicking IH.
- DFSP presents a diagnostic challenge due to its potential resemblance to benign pediatric skin lesions.
- Key clinical features distinguishing IHs from DFSP are highlighted.
Findings:
- Differentiating IHs from DFSP relies on specific clinical findings and "red flags".
- Urgent investigation and multidisciplinary team referral are indicated for suspected DFSP.
- Prompt recognition prevents delayed treatment of potentially aggressive tumors.
Implications:
- Clinicians must maintain a high index of suspicion for IH mimics.
- Understanding "red flags" is essential for accurate and timely diagnosis of pediatric extremity masses.
- Appropriate management strategies for both IHs and their mimics are critical.
Related Concept Videos
01:30Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
01:20The Retinoblastoma Gene
4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
01:06Multipotency and Niche of Bulge Stem Cell
3.6K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.6K