Related Experiment Video
Updated: Jun 24, 2025

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
Published on: February 9, 2024
Risk factors for the development of cervical cancer: analysis of the evidence
Julissa Luvián-Morales1, Sandra Olimpia Gutiérrez-Enríquez2, Víctor Granados-García3
1MICAELA Program, Instituto Nacional de Cancerología, Mexico City, Mexico.
Introduction:
Cervical cancer (CC) is the fourth most prevalent female cancer globally. Understanding its epidemiology is crucial for devising practical strategies suited to geographic and social contexts to attain the global eradication of CC. Hence, this study examined the latest evidence of risk factors contributing to CC development.
Methods:
An independent literature search was conducted on PubMed using MESH terms. The primary sources were meta-analyses published from 2010 to 2023, which detail updated evidence on risk factors associated with CC. Additionally, the quality of the evidence was evaluated using the GRADE system and recommendations were made accordingly.
Results:
The main risk factors related to the cause of CC include co-infections with other sexually transmitted infections, genetic markers, cervicovaginal microbiota, nutritional factors, comorbidities that affect the immune response, smoking, and the use of hormonal contraceptives with a quality evidence based on the GRADE scale moderate.
Conclusions:
Since the necessary cause for CC is persistent cervicovaginal HPV, all the risk factors implicated in the causality of CC act as non-independent cofactors that increase the risk of CC. Thus, changes in public policies aimed at addressing these risk factors are highly recommended and can substantially decrease the risk of CC.
More Related Videos
Related Concept Videos
Cancer Prevention
Some...
Cancer Survival Analysis
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Disorders of the Female Reproductive System
Statistical Methods for Analyzing Epidemiological Data
Factors Affecting Illness
For instance, risk factors are connected to illness,...

