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L Velte1, T Menter2, M M Bornstein3

  • 1Klinik für Oral Health and Medicine, Universitäres Zentrum für Zahnmedizin Basel UZB, Universität Basel, Schweiz. michael.bornstein@unibas.ch.

Swiss Dental Journal
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

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Oral verruciform xanthoma (OVX), a benign oral lesion, was successfully surgically removed. This case highlights OVX management in a patient with chronic graft-versus-host disease (GvHD) post-stem cell transplant.

Area of Science:

  • Oral Pathology
  • Dermatology
  • Oncology

Background:

  • Oral verruciform xanthoma (OVX) is a rare, benign oral lesion.
  • Its etiology remains unclear, with human papillomavirus (HPV) infection unproven.
  • OVX can occur in healthy individuals or those with autoimmune diseases and chronic graft-versus-host disease (GvHD).

Purpose of the Study:

  • To report a case of successful surgical removal of an oral verruciform xanthoma.
  • To discuss the management of OVX in a patient with GvHD.
  • To highlight the long-term implications of GvHD post-stem cell transplantation.

Main Methods:

  • Surgical excision of the oral verruciform xanthoma.
  • Clinical examination and patient history review.
  • Review of literature on OVX and GvHD.
Keywords:
DiagnostikGraft-versus-Host-ReaktionStammzelltransplantationTherapieVerruciformes Xanthom

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Main Results:

  • Successful complete surgical removal of the OVX.
  • The patient, diagnosed with GvHD 14 years post-stem cell transplant for Non-Hodgkin lymphoma, showed no recurrence at the surgical site.
  • The lesion was located on the left buccal mucosa.

Conclusions:

  • Complete surgical excision is the primary treatment for OVX.
  • OVX can be managed effectively even in patients with significant comorbidities like chronic GvHD.
  • This case underscores the importance of vigilant monitoring and management of oral lesions in immunocompromised patients.