Skeletal Editing of Isatins for Heterocycle Molecular Diversity
Tiantian Zhang1, Huangdi Feng1
1Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Abstract:
Isatins have been widely used in the preparation of a variety of heterocyclic compounds, where the skeletal editing of isatins has shown significant advantages for the construction of diverse heterocycles. This review highlights the progress made in the last decade (2013-2023) in the skeletal editing of the isatin scaffold. A series of ring expansion reactions for the construction of quinoline skeleton, quinolone skeleton, polycyclic quinazoline skeleton, medium-sized ring skeleton, as well as a series of ring opening reactions for the generation of 2-(azoly)aniline skeleton by the cleavage of C-C bond and C-N bond are highlighted. It is hoped that this review will provide some understanding of the chemical transformations of isatins and contribute to the further realization of its molecular diversity.
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