Low Expression of GRIM-19 Correlates with Poor Prognosis in Patients with Upper Urinary Tract Urothelial Carcinoma

Feng Tian ¹, Long Lv ¹, Zonglin Liu ²

⁰Key Laboratory of Microenvironment Regulation and Immunotherapy of Urinary Tumors of Liaoning Province, Department of Urology, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, Liaoning, China.

Current Cancer Drug Targets +

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June 7, 2024

View abstract on PubMed

Summary

Lower expression of the gene Retinoid- Interferon-Induced Mortality-19 (GRIM-19) in upper urinary tract urothelial carcinoma (UUTUC) correlates with poorer prognosis. High GRIM-19 levels indicate a better survival outlook for UUTUC patients.

Area Of Science

Oncology
Molecular Biology
Genetics

Background

Upper Urinary Tract Urothelial Carcinoma (UUTUC) is a rare malignancy.
Understanding the molecular mechanisms and prognostic markers in UUTUC is crucial for patient management.

Purpose Of The Study

To investigate the expression levels of the gene Retinoid- Interferon-Induced Mortality-19 (GRIM-19) in UUTUC.
To determine the prognostic significance of GRIM-19 expression in UUTUC patients.

Main Methods

Immunohistochemical (IHC) staining was performed on 70 paired UUTUC samples to assess GRIM-19 expression.
Progression-Free Survival (PFS) and Cancer-Specific Survival (CSS) were evaluated using Kaplan-Meier analysis.
Multivariable Cox regression models were employed to identify independent prognostic factors.

Main Results

GRIM-19 expression was significantly decreased in UUTUC tissues compared to normal tissues, with a shift in cellular localization.
Low GRIM-19 expression was associated with a higher risk of tumor progression and cancer-specific mortality.
GRIM-19 expression, along with lymph node metastasis, emerged as independent predictors for progression and survival in muscle-invasive UUTUC.

Conclusions

Reduced GRIM-19 expression in UUTUC is linked to significantly shorter PFS and CSS.
High GRIM-19 expression is associated with improved PFS, particularly in muscle-invasive cases.
GRIM-19 shows potential as a valuable prognostic biomarker for UUTUC.

Keywords:

Biomarker gene associated with retinoid-interferon induced mortality-19 immunohistochemistry lymph node metastasis. prognosis upper urinary tract urothelial carcinoma