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Emil Buhl1, Bettina Borre Buhl2, Linda Skibsted Kornerup3

  • 1Det Sundhedsvidenskabelige Fakultet, Syddansk Universitet.

Ugeskrift for Laeger
|June 7, 2024
PubMed
Summary

Current vitamin B12 (cobalamin) deficiency treatment lacks a global standard, relying on outdated data. Research is needed to explore new methods like self-injection for better patient outcomes.

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Pharmacology

Background:

  • No international treatment standard for vitamin B12 (cobalamin) deficiency exists.
  • Current treatment practices are based on data more than 50 years old.
  • Existing protocols often guide maintenance therapy by symptom relief over biomarker normalization.

Purpose of the Study:

  • To review current vitamin B12 deficiency treatment standards.
  • To investigate the basis for current treatment recommendations.
  • To highlight the need for updated clinical studies on B12 administration.

Main Methods:

  • Literature review of existing data and treatment guidelines for vitamin B12 deficiency.
  • Analysis of current clinical practices regarding B12 formulation and administration.
  • Identification of gaps in current research and recommendations.

Main Results:

  • Current treatment often involves initial injections followed by oral or injectable maintenance therapy.
  • Treatment intervals are frequently determined by symptom relief rather than biomarker levels.
  • There is a lack of robust clinical evidence supporting current standard practices.

Conclusions:

  • Clinical studies are urgently needed to establish evidence-based treatment standards for B12 deficiency.
  • Investigating different B12 formulations and administration routes, such as subcutaneous self-injection, is recommended.
  • Individualized treatment strategies, potentially including cost-effective self-injection, may improve patient care.

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