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Rasmus Søgaard Hansen¹, Julie Brogaard Larsen^2,3, Pernille Just Vinholt^1,4

¹Blodprøver og Biokemi, Odense Universitetshospital.

Ugeskrift for Laeger

|June 7, 2024

Summary

Antiphospholipid syndrome (APS) involves antibodies against phospholipid-binding proteins, increasing risks of blood clots and pregnancy issues. This review covers the 2023 classification criteria and management of APS.

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Area of Science:

Immunology
Rheumatology
Hematology

Background:

Antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) targeting phospholipid-binding proteins.
APS significantly elevates the risk of thromboembolism and obstetric complications.
Understanding APS is crucial for managing associated health risks.

Approach:

This review summarizes the 2023 international classification criteria for APS.
It details the six clinical and two laboratory domains essential for diagnosis.
The review outlines current specialist approaches to APS diagnosis and treatment.

Key Points:

The 2023 criteria encompass venous, arterial, and microvascular events, obstetric issues, cardiac valve disease, and thrombocytopenia.

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Laboratory confirmation requires lupus anticoagulant, anti-cardiolipin, or anti-β2-glycoprotein-I antibodies.

Accurate diagnosis relies on integrating clinical and laboratory findings.

Conclusions:

APS diagnosis and management require specialized medical expertise.
This review provides a comprehensive overview for clinicians.
Adherence to updated criteria ensures optimal patient care for APS.