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Correlation between elevated HCLS1 levels and heart failure: A diagnostic biomarker

Chunguang Li1, Li Zhang2, Long Zhang3

  • 1Clinical Lab Center, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Medicine
|June 7, 2024
PubMed

Insights

Hematopoietic cell-specific lyn substrate 1 (HCLS1) is highly expressed in heart failure (HF). This study identifies HCLS1 and other core genes involved in HF pathogenesis, suggesting potential diagnostic markers.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Genomics

Background:

  • The relationship between hematopoietic cell-specific lyn substrate 1 (HCLS1) expression and heart failure (HF) is not well understood.
  • Investigating gene expression patterns in HF can reveal novel insights into disease mechanisms.

Purpose of the Study:

  • To explore the correlation between HCLS1 expression and heart failure.
  • To identify key genes and pathways involved in the pathogenesis of heart failure.

Main Methods:

  • Analysis of heart failure datasets (GSE192886, GSE196656) from the Gene Expression Omnibus (GEO) database.
  • Utilized weighted gene co-expression network analysis, protein-protein interaction (PPI) networks, and functional enrichment analysis.
  • Screened microRNAs (miRNAs) targeting differentially expressed genes (DEGs) using TargetScan.

Main Results:

  • Identified 500 DEGs primarily associated with leukocyte activation, protein phosphorylation, cell adhesion, PI3K Akt, Notch signaling pathways, and right ventricular cardiomyopathy.
  • The PPI network highlighted 15 core genes, including HCLS1, FERMT3, and LYN.
  • Four genes (EP300, CD53, HCLS1, LYN) showed high expression in HF tissues and were linked to cardiovascular diseases, inflammation, and necrosis.

Conclusions:

  • HCLS1 is significantly upregulated in heart failure tissues.
  • The identified core genes and pathways offer potential targets for understanding and treating heart failure.
  • HCLS1 may serve as a potential biomarker for heart failure.

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