Ability of enzymes to remove Candida

Area of Science:

• Biochemistry
• Microbiology
• Biomaterials Science

Background:

• Denture stomatitis is a common oral condition often caused by Candida albicans infection.
• Candida albicans adheres to acrylic resin, the material used in dentures, leading to persistent infections.
• Effective denture hygiene is crucial for preventing and managing oral candidiasis.

Purpose of the Study:

• To investigate the efficacy of yeast lytic enzymes and proteolytic enzymes in removing Candida albicans from acrylic resin surfaces.
• To assess the potential of these enzymes as components of novel denture cleansers.

Main Methods:

• Acrylic resin coupons were inoculated with Candida albicans.
• Enzymatic treatments using yeast lytic enzymes and proteolytic enzymes were applied to the contaminated surfaces.
• The removal efficiency of Candida albicans was quantified after enzymatic treatment.

Main Results:

• Both yeast lytic enzymes and proteolytic enzymes demonstrated significant removal of Candida albicans from acrylic resin.
• The enzymatic treatments effectively disrupted yeast adherence to the denture material.
• Enzymes offer a targeted approach to reducing microbial load on denture surfaces.

Conclusions:

• Yeast lytic enzymes and proteolytic enzymes are effective in eliminating Candida albicans from acrylic resin.
• These enzymes represent a promising biochemical approach for developing new denture cleansers.
• Further research into enzyme-based denture cleansers could lead to improved patient outcomes in managing denture stomatitis.