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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Updated: Jun 24, 2025

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Non-coding RNAs Function in Periodontal Ligament Stem Cells.

Wei Zhai1, Jie Gao1, Wen Qin1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, the Fourth Military Medical University, Xi'an, China.

Stem Cell Reviews and Reports
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs regulate stem cell functions, impacting periodontal tissue regeneration. These molecules show promise as therapeutic targets for periodontal diseases and orthodontic treatments.

Keywords:
Mechanical StressNon-coding RNAOrthodonticsPeriodontal Ligament stem CellsPeriodontitis

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Area of Science:

  • Molecular Biology
  • Stem Cell Biology
  • Periodontal Medicine

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators in basic molecular mechanisms.
  • ncRNAs influence stem cell self-renewal, osteogenesis, proliferation, and differentiation.
  • Periodontal ligament stem cells (PDLSCs) are vital for periodontal tissue regeneration.

Purpose of the Study:

  • To summarize the current research on ncRNAs in PDLSC molecular mechanisms.
  • To explore the regulatory roles of ncRNAs in PDLSC proliferation and differentiation.
  • To identify potential therapeutic targets for periodontal diseases using ncRNAs.

Main Methods:

  • Literature review of studies on ncRNAs and PDLSCs.
  • Analysis of ncRNA involvement in stem cell self-renewal and osteogenesis.
  • Investigation of ncRNA regulation in periodontal tissue regeneration.

Main Results:

  • ncRNAs significantly affect stem cell self-renewal and osteogenesis.
  • ncRNAs regulate PDLSC proliferation and induce bone differentiation.
  • ncRNAs demonstrate regulatory effects on PDLSC proliferation and differentiation in stomatology.

Conclusions:

  • ncRNAs play a critical role in PDLSC biology.
  • ncRNAs are potential therapeutic targets for periodontal diseases like periodontitis.
  • Further research on ncRNAs in PDLSCs can advance periodontal regenerative medicine and orthodontic treatments.