Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

168
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
168
Stress and Mental Health01:30

Stress and Mental Health

102
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
102
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

164
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
164
Borderline Personality Disorder01:25

Borderline Personality Disorder

40
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
40
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

203
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
203

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing a Specialty Bipolar Clinic: The National Network of Depression Centers Consensus Recommendations.

Bipolar disorders·2026
Same author

Enhancing Affective Cognitive Control in Bipolar Disorder Using Transcranial Alternating Current Stimulation: A Double-Blind, Randomized, Sham-Controlled Clinical Trial and Proof of Concept Study.

Bipolar disorders·2026
Same author

Context Memory Discrimination and Recognition in Humans: Development of a Novel Cognitive Task.

JMIR formative research·2026
Same author

Cerebellum-Cerebrum Dynamics During Gaze Processing in Schizophrenia: Evidence for Social-Cognitive Modulation and Associations with Social Functioning Across Independent Samples.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

The link between basic visual processing and higher-level social cognition: Eye gaze perception as a bridge in a transdiagnostic sample enriched with social dysfunction.

Psychological medicine·2026
Same author

Time-Related Considerations for Modeling Event-Based Data Collected via Ecological Momentary Assessment.

Advances in methods and practices in psychological science·2026

Related Experiment Video

Updated: Jun 24, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.7K

Longitudinal Interplay Between Alcohol Use, Mood, and Functioning in Bipolar Spectrum Disorders.

Sarah H Sperry1,2, Audrey R Stromberg1,2, Victoria A Murphy2

  • 1Department of Psychology, University of Michigan, Ann Arbor.

JAMA Network Open
|June 7, 2024
PubMed
Summary

Alcohol use is linked to mood instability and poor work functioning in bipolar disorder (BD). However, worsening mood symptoms in BD do not predict future alcohol use, highlighting the need for integrated treatment.

More Related Videos

Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

252
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

888

Related Experiment Videos

Last Updated: Jun 24, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.7K
Developing a Rat Model for Bipolar Disorder
04:44

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

252
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

888

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Psychology

Background:

  • Alcohol use disorder (AUD) frequently co-occurs with bipolar disorder (BD), significantly worsening patient outcomes.
  • Concurrent treatment for BD and AUD is under-researched and clinically neglected, necessitating a deeper understanding of their interplay.
  • Characterizing the dynamic relationship between alcohol use and mood symptoms in BD is crucial for improving patient care and prognosis.

Purpose of the Study:

  • To investigate longitudinal alcohol use patterns in individuals diagnosed with bipolar disorder (BD).
  • To examine the temporal associations between alcohol consumption, mood states (depression, mania/hypomania), anxiety levels, and overall functioning over time.
  • To identify how these factors influence each other longitudinally in a BD cohort.

Main Methods:

  • A cohort study utilizing data from the Prechter Longitudinal Study of Bipolar Disorder (PLS-BD).
  • Inclusion criteria: diagnosis of Bipolar I (BDI) or Bipolar II (BDII) disorder with a minimum of 5 years of study participation.
  • Data collection spanned February 2006 to April 2022, with follow-up durations ranging from 5 to 16 years. Standardized assessments measured alcohol use, mood symptoms, anxiety, and functioning.

Main Results:

  • Problematic alcohol use correlated with increased depressive and manic/hypomanic symptoms and decreased workplace functioning in the subsequent six months.
  • Conversely, elevated depressive or manic/hypomanic symptoms did not predict increased future alcohol use.
  • These associations were more pronounced in Bipolar II disorder compared to Bipolar I disorder. Alcohol use showed no significant association with anxiety levels over time.

Conclusions:

  • Alcohol use, irrespective of AUD diagnosis, is associated with mood instability and impaired work functioning in individuals with BD.
  • Increased mood symptoms in BD do not appear to drive subsequent alcohol use.
  • There is a critical need for integrated, dimensional, and longitudinal assessment and management strategies for alcohol use within BD research and clinical practice.