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Mapping Strategies for Reaching Socioeconomically Disadvantaged Populations in Clinical Trials
Maria I Florez1, Emily Botto1, Jennifer Y Kim1
1Tufts Center for the Study of Drug Development, Tufts University School of Medicine, Boston, Massachusetts.
JAMA Network Open
|June 7, 2024
Summary
For-profit clinical research sites use more strategies to recruit socioeconomically disadvantaged patients than nonprofit sites. However, most sites collect little socioeconomic data, highlighting a need for improved patient diversity in clinical trials.
Area of Science:
- Clinical Research Operations
- Health Equity
- Socioeconomic Disparities in Healthcare
Background:
- Socioeconomically disadvantaged individuals face barriers to clinical trial participation.
- Improved representation of diverse populations in clinical trials is crucial for generalizability.
- Current recruitment strategies may not adequately address the needs of socioeconomically diverse groups.
Purpose of the Study:
- To evaluate the effectiveness of current US clinical research site recruitment and enrollment strategies.
- To determine if these strategies adequately include patients from socioeconomically disadvantaged backgrounds.
- To identify differences in strategy adoption based on research site ownership.
Main Methods:
- A cross-sectional survey study was conducted from April to July 2023.
- Online surveys were distributed to US clinical research sites to assess recruitment strategies and data collection practices.
- Data analysis compared strategy adoption between for-profit and nonprofit/governmental sites.
Main Results:
- A total of 492 responses were received from 381 US clinical research sites.
- For-profit sites reported higher utilization of strategies like after-hours visits and financial compensation compared to nonprofit/governmental sites.
- Most sites, regardless of ownership, collected minimal socioeconomic data, with only 7.2% of for-profit and 13.0% of nonprofit/governmental sites collecting annual income information.
Conclusions:
- A significant association exists between clinical research site ownership type and the use of strategies to engage socioeconomically diverse populations.
- The limited collection of socioeconomic data by most clinical research sites hinders efforts to understand and address participation barriers.
- Enhanced adoption of targeted engagement strategies, especially by nonprofit/governmental sites, could improve the inclusion of socioeconomically disadvantaged patients in clinical research.
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