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U-Shaped Relationship Between Fibrinogen Level and 10-year Mortality in Patients With Acute Coronary Syndrome:

Yi Ming Li1, Yuheng Jia1, Lin Bai1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Sichuan Province, Chengdu City, China.

JMIR Public Health and Surveillance
|June 7, 2024
PubMed

Insights

Fibrinogen is a significant predictor of long-term mortality in acute coronary syndrome (ACS) patients. A U-shaped relationship indicates that both very low and high fibrinogen levels are associated with increased risk.

Area of Science:

  • Cardiology
  • Clinical Research
  • Biomarkers

Background:

  • Acute coronary syndrome (ACS) is a leading cause of mortality worldwide.
  • Identifying reliable prognostic markers for long-term outcomes in ACS patients is crucial for effective clinical management.

Purpose of the Study:

  • To investigate the association between fibrinogen levels and 10-year mortality in patients with acute coronary syndrome (ACS).
  • To characterize the nature of the relationship between fibrinogen and mortality in this patient cohort.

Main Methods:

  • Retrospective analysis of patient data from a cohort with diagnosed ACS.
  • Statistical modeling to assess fibrinogen as an independent predictor of 10-year all-cause mortality.
  • Examination of the dose-response relationship between fibrinogen levels and mortality risk.

Main Results:

  • Fibrinogen was identified as an independent risk factor for 10-year mortality in ACS patients.
  • A significant U-shaped nonlinear relationship was observed between fibrinogen levels and mortality.
  • Both low and high fibrinogen concentrations were associated with increased long-term mortality risk.

Conclusions:

  • Fibrinogen monitoring is important for risk stratification in ACS patients.
  • The findings suggest potential benefits of considering long-term anti-inflammatory strategies in managing ACS patients, particularly those with abnormal fibrinogen levels.

Keywords:
10-year mortalityKaplan-Meier analysisacute coronary syndromeall-cause mortalitycoronary artery diseasecubic-spline curvefibrinogenheart diseaseinflammatory factormortalitymyocardialregression modelretrospective studyrisk factor

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