Are Oxidative Stress Biomarkers Reliable Part of Multimarker Panel in Female Patients with Type 2 Diabetes Mellitus?
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View abstract on PubMed
Summary
This summary is machine-generated.Oxidative stress biomarkers like malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were not superior to traditional cardiometabolic markers for predicting type 2 diabetes (T2D) in women. Traditional markers independently predicted T2D risk.
Area Of Science
- Biochemistry
- Endocrinology
- Metabolic Diseases
Background
- Oxidative stress and inflammation are central to metabolic diseases like type 2 diabetes (T2D).
- Previous studies on redox homeostasis in T2D have yielded conflicting results.
- Reliable biomarkers for T2D risk assessment are needed.
Purpose Of The Study
- To evaluate the predictive reliability of oxidative stress biomarkers (MDA, AOPP, CAT) against traditional cardiometabolic parameters for T2D in a female cohort.
- To identify factors independently associated with T2D in women.
Main Methods
- A cohort of 214 women (40.6% with T2D) was studied.
- Principal Component Analysis (PCA) was used to analyze anthropometric, cardiometabolic, and redox status markers.
- Multivariate binary regression analysis assessed independent predictors of T2D.
Main Results
- In the T2D group, MDA and AOPP levels were lower, while CAT activity was higher compared to controls.
- A factor comprising traditional cardiometabolic markers (waist circumference, triglycerides, uric acid, hs-CRP, HDL-C) independently predicted T2D.
- A factor of oxidative stress markers (MDA, AOPP) did not independently predict T2D after adjusting for confounders.
- Increased traditional marker factor significantly elevated T2D probability (OR = 3.319).
Conclusions
- Oxidative stress biomarkers (MDA, AOPP, CAT) are not superior to traditional cardiometabolic markers for T2D prediction in women.
- Traditional cardiometabolic markers remain crucial for assessing T2D risk in this population.
- Further research including both genders is necessary to confirm these findings.
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