Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen vacancy-mediated photothermal CO<sub>2</sub> methanation over Ni/Ce-Zr solid solution catalysts.

Journal of colloid and interface science·2026
Same author

A Guanine Ribonucleotide Atypically Adaptive to the <i>Syn</i> Glycosidic Conformation in a Human Telomeric DNA-TERRA RNA Hybrid G-Quadruplex with (3 + 1) Mixed Strand Orientations Studied by NMR.

Journal of the American Chemical Society·2026
Same author

Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers with Overweight/Obesity and Their Offspring: An 8- to 10-Year Follow-Up Study.

Advances in therapy·2026
Same author

Analysis of drug use and expenditure of conventional and biological disease-modifying anti-rheumatic drugs: a study from Northwest China.

Clinical rheumatology·2026
Same author

Comparison of Weekly Training Loads in Division I Lacrosse Athletes Using Hormonal Contraceptives Versus Nonusers.

Journal of strength and conditioning research·2026
Same author

Excitation Dependent Nonconventional Afterglow for 6D Dynamic Encryptions.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Jun 24, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.2K

Macrocyclic Neutralizer to Polybrene via Direct Host-Guest Complexation.

Yahan Zhang1, Xiang Yu1, Di Gao1

  • 1State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Journal of Medicinal Chemistry
|June 7, 2024
PubMed
Summary
This summary is machine-generated.

A novel macrocyclic neutralizer, SQP3, effectively reverses complications caused by Hexadimethrine bromide (HB). This compound prevents red blood cell aggregation and tissue damage, improving survival rates in mice.

More Related Videos

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

6.7K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.7K

Related Experiment Videos

Last Updated: Jun 24, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

13.2K
Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions
05:37

Label-Free Quantitative Proteomics Workflow for Discovery-Driven Host-Pathogen Interactions

Published on: October 20, 2020

6.7K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.7K

Area of Science:

  • Biochemistry
  • Materials Science
  • Toxicology

Background:

  • Hexadimethrine bromide (HB) is used as a heparin antidote and in gene therapy.
  • HB causes adverse effects like red blood cell aggregation and tissue damage.

Purpose of the Study:

  • To synthesize and evaluate a novel macrocyclic neutralizer, SQP3, for reversing HB-induced toxicity.
  • To investigate the host-guest complexation mechanism between SQP3 and HB.

Main Methods:

  • Synthesis of a water-soluble quaterphen[3]arene (SQP3) with sulfonate moieties.
  • Binding affinity studies using association constants.
  • In vitro cellular assays to assess reactive oxygen species and apoptosis.
  • In vivo studies in mice to evaluate neutralization efficacy and survival rates.

Main Results:

  • SQP3 demonstrated strong binding affinity for HB (K_a = 4.73 × 10^7 M^-1).
  • SQP3 effectively reversed HB-induced red blood cell aggregation and blood coagulation.
  • Complexation with SQP3 reduced oxidative stress and suppressed cell apoptosis.
  • In vivo studies showed complete protection against HB toxicity and improved survival from 20% to 100%.

Conclusions:

  • SQP3 is a potent neutralizer for Hexadimethrine bromide.
  • SQP3 offers a promising therapeutic strategy to mitigate HB-related complications.
  • This macrocyclic neutralizer has significant potential in clinical applications involving HB.