Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating
Houyu Zhao1, Kun Liang2, Zeyuan Yu1
1Department of Diving and Hyperbaric Medicine, Navy Special Medical Center, Naval Medical University, Shanghai 200433, China.
Neuroscience Research
|June 7, 2024
Summary
Prolonged underwater exercise causes anxiety and cognitive decline in rats. Preconditioning with hyperbaric oxygen (HBO-PC) at a specific frequency protected the brain by reducing inflammation.
Area of Science:
- Neuroscience
- Exercise Physiology
- Hyperbaric Medicine
Background:
- Underwater exercise poses risks to brain function.
- Prolonged exercise in aquatic environments lacks investigation regarding cognitive effects.
- Hyperbaric oxygen preconditioning (HBO-PC) shows neuroprotective potential.
Purpose of the Study:
- To investigate the cognitive impact of prolonged underwater exercise (PUE).
- To explore the neuroprotective role of HBO-PC in an underwater setting.
Main Methods:
- A rat model of PUE was established through 3-hour swimming in a simulated hyperbaric chamber (2.0 ATA).
- Rats received HBO-PC (2.5 ATA) administered 1, 3, or 5 times before PUE.
- Cognitive function, anxiety-like behaviors, hippocampal function, and neuroinflammation markers were assessed.
Main Results:
- PUE induced anxiety-like behaviors, cognitive impairment, hippocampal dysfunction, and neuroinflammation.
- Three sessions of HBO-PC effectively mitigated anxiety and cognitive deficits.
- HBO-PC treatment reduced microglia activation and shifted them towards a neuroprotective phenotype.
Conclusions:
- Prolonged underwater exercise negatively affects cognitive function and behavior.
- A specific frequency of hyperbaric oxygen preconditioning (3 sessions) offers a potential intervention to protect the brain during underwater exercise.
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