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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Transgenic Organisms

Transgenic Organisms

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

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Related Experiment Video

Updated: Jun 24, 2025

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Transdermal gene delivery.

Wentao Zhang¹, Yunlong Jiao¹, Ziru Zhang¹

¹State Key Laboratory of Advanced Drug Delivery and Release Systems, Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|June 7, 2024

Summary

This summary is machine-generated.

Transdermal gene delivery offers a promising alternative to traditional methods, enhancing safety and efficiency for vaccination, cancer, and autoimmune disease treatments. This approach leverages innovative formulations and devices for improved therapeutic outcomes.

Keywords:

Drug delivery Drug formulations Gene therapy Medical devices Transdermal delivery

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Last Updated: Jun 24, 2025

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

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Published on: May 5, 2014

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Area of Science:

Biotechnology and Biomedical Engineering
Gene Therapy and Drug Delivery

Background:

Gene delivery is crucial for vaccination, cancer, and autoimmune disease therapies.
Current methods (intravenous, local injection) face limitations in biosafety, targeting, retention, and efficiency.

Purpose of the Study:

To review recent advances in transdermal gene delivery.
To explore the impact of transdermal routes on gene delivery efficiency and patient experience.
To discuss the prospects of transdermal gene delivery.

Main Methods:

Review of foundational and clinical research on transdermal gene delivery.
Analysis of drug formulations and medical devices enabling transdermal gene delivery.

Main Results:

Transdermal drug delivery strategies show potential for improved therapeutic outcomes.
Emerging research highlights the role of the transdermal route in enhancing gene delivery efficiency.

Conclusions:

Transdermal gene delivery presents a viable alternative to conventional methods.
Further research and development in formulations and devices are key to realizing its full therapeutic potential.