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Related Experiment Video

Updated: Jun 24, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

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Ultrafast light-activated polymeric nanomotors.

Jianhong Wang1, Hanglong Wu1, Xiaowei Zhu2

  • 1Bio-Organic Chemistry, Departments of Biomedical Engineering and Chemical Engineering & Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB, Eindhoven, The Netherlands.

Nature Communications
|June 7, 2024
PubMed
Summary

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Researchers developed light-propelled biodegradable nanomotors using gold nanoparticles on polymersomes. These nanomotors exhibit controllable motion and high speeds, enabling active cargo delivery into living cells for biomedical applications.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Synthetic micro/nanomotors are crucial for active transport, with applications in environmental remediation and nanomedicine.
  • Developing fast-moving, biodegradable polymeric nanomotors remains a significant challenge in the field.

Purpose of the Study:

  • To create a light-propelled, biodegradable polymeric nanomotor.
  • To investigate the mechanism behind the nanomotor's motion and its potential for cargo delivery.

Main Methods:

  • Fabrication of biodegradable polymersomes (stomatocytes) functionalized with gold nanoparticles (Au NP).
  • Utilizing electrostatic and hydrogen bond interactions for Au NP attachment.
  • Employing cryogenic transmission electron microscopy (cryo-TEM) and cryo-electron tomography (cryo-ET) for 3D characterization.

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Last Updated: Jun 24, 2025

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Published on: March 13, 2019

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Construction and Operation of a Light-driven Gold Nanorod Rotary Motor System
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Main Results:

  • Achieved controllable motion with velocities up to 125 μm s⁻¹.
  • Demonstrated that non-uniform Au NP distribution along the z-axis drives nanomotor motility.
  • Successfully utilized nanomotors for active cargo delivery into living cells.

Conclusions:

  • Introduced a novel approach for constructing robust, biodegradable soft nanomotors.
  • Highlighted the potential of these nanomotors in biomedicine, particularly for intracellular cargo delivery.
  • Provided a detailed 3D analysis explaining the propulsion mechanism based on nanoparticle distribution.