The effect of pre-emptive oral pregabalin on opioid consumption in patients undergoing laparoscopic sleeve gastrectomy with an analysis of intraoperative hemodynamic stability and quality of recovery: study protocol for a randomized, prospective, double-blind study
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View abstract on PubMed
Summary
This summary is machine-generated.Preemptive pregabalin may reduce opioid use and improve pain control in obese patients after laparoscopic sleeve gastrectomy. This study investigates its efficacy and safety in multimodal analgesia.
Area Of Science
- Anesthesiology
- Bariatric Surgery
- Pharmacology
Background
- Obese patients undergoing laparoscopic sleeve gastrectomy (LSG) face increased risks of opioid-related side effects.
- Multimodal analgesia strategies are explored to minimize opioid exposure.
- Pregabalin is a potential adjunct in opioid-sparing regimens for LSG.
Purpose Of The Study
- To evaluate the efficacy and safety of preemptive pregabalin (150 mg) in obese patients undergoing LSG.
- To assess the impact of pregabalin on opioid consumption, pain scores, and side effects.
- To contribute objective data on pregabalin's role in multimodal analgesia for LSG.
Main Methods
- Prospective, double-blind, randomized controlled trial with 1:1 allocation.
- Intervention group received pregabalin 150 mg preoperatively; control group received placebo.
- Primary outcome: total oxycodone consumption in 24 hours post-surgery. Secondary outcomes: pain scores (NRS), sedation, PONV, desaturation, vision changes, hemodynamics, and patient comfort (QoR-40).
Main Results
- This section is to be filled once the study is completed and results are available.
Conclusions
- The study aims to determine if preemptive pregabalin is effective and safe for multimodal analgesia in LSG patients.
- Results may inform clinical practice and potentially lead to revised recommendations for pregabalin use in this population.
- This trial will provide valuable data on opioid-sparing strategies in obese surgical patients.
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