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The effect of pre-emptive oral pregabalin on opioid consumption in patients undergoing laparoscopic sleeve
Piotr Mieszczanski1, Grzegorz Gorniewski2, Marek Janiak2
11St Department of Anesthesiology and Intensive Care, Medical University of Warsaw, Lindleya 4, Warsaw, 02-005, Poland. piotr.mieszczanski@gmail.com.
Trials
|June 7, 2024
Summary
Preemptive pregabalin may reduce opioid use and improve pain control in obese patients after laparoscopic sleeve gastrectomy. This study investigates its efficacy and safety in multimodal analgesia.
Area of Science:
- Anesthesiology
- Bariatric Surgery
- Pharmacology
Background:
- Obese patients undergoing laparoscopic sleeve gastrectomy (LSG) face increased risks of opioid-related side effects.
- Multimodal analgesia strategies are explored to minimize opioid exposure.
- Pregabalin is a potential adjunct in opioid-sparing regimens for LSG.
Purpose of the Study:
- To evaluate the efficacy and safety of preemptive pregabalin (150 mg) in obese patients undergoing LSG.
- To assess the impact of pregabalin on opioid consumption, pain scores, and side effects.
- To contribute objective data on pregabalin's role in multimodal analgesia for LSG.
Main Methods:
- Prospective, double-blind, randomized controlled trial with 1:1 allocation.
- Intervention group received pregabalin 150 mg preoperatively; control group received placebo.
- Primary outcome: total oxycodone consumption in 24 hours post-surgery. Secondary outcomes: pain scores (NRS), sedation, PONV, desaturation, vision changes, hemodynamics, and patient comfort (QoR-40).
Main Results:
- This section is to be filled once the study is completed and results are available.
Conclusions:
- The study aims to determine if preemptive pregabalin is effective and safe for multimodal analgesia in LSG patients.
- Results may inform clinical practice and potentially lead to revised recommendations for pregabalin use in this population.
- This trial will provide valuable data on opioid-sparing strategies in obese surgical patients.
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