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No causal association between insomnia and bladder cancer: a bidirectional two-sample Mendelian randomization study
Lihuan Du1, Bohan Wang2, Jiaming Wen2
1Department of Urology, The Second Affiliated Hospital of Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, China. dlh1984@zju.edu.cn.
European Journal of Medical Research
|June 7, 2024
Summary
This study found no causal link between insomnia and bladder cancer. Mendelian randomization analysis confirmed that neither condition appears to cause the other, supporting current evidence.
Area of Science:
- Genetics
- Epidemiology
- Oncology
Background:
- Observational studies suggest a possible link between insomnia and bladder cancer.
- The causal relationship between insomnia and bladder cancer remains unclear.
Purpose of the Study:
- To investigate the potential causal relationship between insomnia and bladder cancer using a bidirectional two-sample Mendelian randomization analysis.
Main Methods:
- Utilized summary data from genome-wide association studies (GWAS) for insomnia and bladder cancer.
- Employed various Mendelian randomization methods, including inverse variance weighted (IVW) and weighted median.
- Assessed for pleiotropy and heterogeneity, and conducted sensitivity analyses.
Main Results:
- No significant causal effect of insomnia on bladder cancer risk was detected (IVW OR=0.761, P=0.76).
- No significant causal effect of bladder cancer on insomnia risk was detected (IVW OR=1.47, P=0.24).
- Sensitivity analyses and heterogeneity/pleiotropy tests supported the findings.
Conclusions:
- This Mendelian randomization study found no evidence to support a causal relationship between insomnia and bladder cancer.
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