Impact of TLR9 and TLR7 gene polymorphisms on prognosis and survival of patients with oral squamous cell carcinoma
Miroslav Obrenović1, Gordana Šupić2, Satoru Miyabe3
1Faculty of Medicine, University of East Sarajevo, Foča, Bosnia and Herzegovina; Department for ENT and Maxillofacial Surgery, University Hospital Foča, Foča, Bosnia and Herzegovina.
Biomolecules & Biomedicine
|June 8, 2024
Summary
The TLR9 rs187084 CC genotype may indicate poorer survival and tumor progression in oral squamous cell carcinomas (OSCC). However, these genetic variations did not increase OSCC susceptibility but were linked to high alcohol consumption.
Area of Science:
- Immunogenetics
- Oncology
- Molecular Biology
Background:
- Oral squamous cell carcinomas (OSCC) have high recurrence and low survival rates despite treatment advances.
- Toll-like receptors (TLRs) play a role in immune surveillance and antitumor responses.
- Genetic variations in TLRs may influence cancer development and progression.
Purpose of the Study:
- To investigate the association between TLR7 rs3853839 and TLR9 rs187084 gene polymorphisms and OSCC risk.
- To evaluate the correlation of these polymorphisms with clinicopathological features and survival outcomes in OSCC patients.
- To explore potential links between these polymorphisms and lifestyle factors like alcohol consumption.
Main Methods:
- Genotyping of TLR7 rs3853839 and TLR9 rs187084 polymorphisms using real-time PCR.
- Study included 95 HPV-negative OSCC patients and 107 healthy controls.
- Statistical analysis included comparisons of genotype frequencies, clinicopathological data, survival rates, and alcohol consumption.
Main Results:
- The TLR9 rs187084 CC genotype was associated with lymph node metastases and advanced stage III disease.
- Patients with the TLR9 rs187084 CC genotype showed significantly lower overall survival rates.
- Both TLR9 rs187084 and TLR7 rs3853839 polymorphisms were linked to high alcohol consumption; no association with OSCC susceptibility was found.
Conclusions:
- The TLR9 rs187084 polymorphism, specifically the CC genotype, may serve as a marker for poor survival and tumor progression in OSCC.
- Investigated TLR polymorphisms were not associated with increased OSCC susceptibility.
- A significant association was observed between TLR polymorphisms and high alcohol consumption patterns.
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