Search

Search

Home
...
Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Analysis of prognostic factors and construction of prognostic models for invasive lobular carcinoma of the breast

Analysis of prognostic factors and construction of prognostic models for invasive lobular carcinoma of the breast

Lin Cheng ¹, Jianlin Wang ², Liming Tang ³

Lin Cheng ¹, Jianlin Wang ², Liming Tang ³

¹Department of Breast Surgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Postdoctoral Station of Changzhou Second People's Hospital, Changzhou, China.
²Department of Radiotherapy, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China.
³Department of Gastrointestinal Surgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Postdoctoral Station of Changzhou Second People's Hospital, Changzhou, China.

⁰Department of Breast Surgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Postdoctoral Station of Changzhou Second People's Hospital, Changzhou, China.

Biomolecules & Biomedicine +

|

June 8, 2024

Related Experiment Videos

These videos have been matched automatically. Contact us if they are not relevant.

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities

Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities

Published on: May 10, 2024

See all related videos

View abstract on PubMed

Summary

This summary is machine-generated.

Invasive lobular carcinoma (ILC) patients show better survival than invasive ductal carcinoma (IDC) patients. Prognostic factors for ILC include TNM stage, age, ER/PR status, and HER2 status, aiding survival prediction.

Area Of Science

Oncology
Cancer Research
Epidemiology

Background

Invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) are the most common types of breast cancer.
There is ongoing debate regarding differences in overall survival (OS) between ILC and IDC.

Purpose Of The Study

To compare the overall survival (OS) between ILC and IDC.
To identify prognostic factors for ILC patients.
To develop a nomogram for predicting OS in ILC patients.

Main Methods

Retrospective cohort analysis using the SEER Cancer Database (2000-2019).
Propensity score matching (PSM) to balance baseline characteristics.
Multivariate Cox regression to identify prognostic factors and construct a nomogram.

Main Results

After PSM, ILC patients demonstrated a better prognosis than IDC patients.
Independent prognostic factors for ILC OS included TNM stage, age >70, radiotherapy, surgery, ER, PR, and HR-/HER2+ subtype.
Surgery and radiotherapy were associated with reduced mortality risk; chemotherapy did not show a significant benefit.

Conclusions

ILC patients generally have a better prognosis than IDC patients.
A predictive nomogram incorporating identified prognostic factors can aid in OS estimation for ILC.
The findings support clinical decision-making and patient counseling regarding ILC prognosis.

Related Experiment Videos

These videos have been matched automatically. Contact us if they are not relevant.

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities

Construction of An Orthotopic Xenograft Model of Non-Small Cell Lung Cancer Mimicking Disease Progression and Predicting Drug Activities

Published on: May 10, 2024

See all related videos

Related Concept Videos

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies